| Non Conference |
| 7:00pm | Apollo-Ridge at Jeannette | 28-42 |
| 7:00pm | Armstrong at Hampton | 42-30 |
| 7:00pm | Beaver Falls at Imani Christian | 0-34 |
| 7:00pm | Belle Vernon at Aliquippa | PPD |
| 7:00pm | Beth-Center at Leechburg | 8-42 |
| 7:00pm | Bethel Park at Mars | 49-13 |
| 7:00pm | Bishop Canevin at Seton LaSalle | 14-21 |
| 7:00pm | Brashear at Butler | 0-42 |
| 7:00pm | Burgettstown at Bentworth | 11-6 |
| 7:00pm | California at Cornell | 3-27 |
| 7:00pm | Carlynton at Avella | 21-0 |
| 7:00pm | Carmichaels at Sto-Rox | PPD |
| 7:00pm | Carrick at Albert Gallatin | 6-42 |
| 7:00pm | Central Catholic at Pine-Richland | 17-22 |
| 7:00pm | Chartiers Valley at West Allegheny | PPD |
| 7:00pm | Chartiers-Houston at Springdale | 54-0 |
| 7:00pm | Clairton at Serra Catholic | 43-0 |
| 7:00pm | Deer Lakes at South Park | 35-22 |
| 7:00pm | East Allegheny at Southmoreland | 14-49 |
| 7:00pm | Elizabeth Forward at Highlands | 52-53 3OT |
| 7:00pm | Fox Chapel at Baldwin | 38-7 |
| 7:00pm | Franklin Regional at Hempfield | 49-26 |
| 7:00pm | Freedom at Rochester | PPD |
| 7:00pm | Freeport at Derry Area | 7-21 |
| 7:30pm | Gateway at North Allegheny | 7-42 |
| 7:00pm | Hollidaysburg at Allderdice | 42-0 |
| 7:00pm | Hopewell at New Castle | 19-42 |
| 7:00pm | Jefferson-Morgan at Waynesburg Central | 34-28 |
| 7:00pm | Keystone Oaks at Quaker Valley | PPD |
| 7:00pm | Laurel at Mohawk | 27-32 |
| 7:00pm | Laurel Highlands at Ambridge | PPD |
| 7:00pm | Ligonier Valley at Greensburg Salem | 14-43 |
| 7:00pm | Mapletown at Frazier | 0-36 |
| 7:00pm | McGuffey at Trinity | 6-49 |
| 7:00pm | McKeesport at Peters Township | 7-42 |
| 7:00pm | Meadville at Connellsville | 48-41 4OT |
| 7:00pm | Montour at Moon | PPD |
| 7:00pm | Mount Pleasant at Greensburg Central Catholic | 36-34 OT |
| 7:30pm | Mt. Lebanon at Penn-Trafford | 7-28 |
| 7:00pm | Neshannock at Union | 48-20 |
| 7:00pm | North Catholic at Knoch | 17-28 |
| 7:00pm | Northgate at Riverside | 29-25 |
| 7:00pm | Norwin at Kiski Area | 33-21 |
| 7:00pm | Our Lady of Sacred Heart at Fort Cherry | 14-41 |
| 7:00pm | Penn Hills at Woodland Hills | 6-26 |
| 7:00pm | Perry Traditional Academy at Uniontown | 6-34 |
| 7:00pm | Plum at Latrobe | 18-32 |
| 7:00pm | Ringgold at Indiana | 13-14 OT |
| 7:00pm | Riverview at Valley | 38-36 |
| 7:00pm | Seneca Valley at North Hills | 6-13 |
| 7:00pm | Shady Side Academy at Burrell | 42-7 |
| 7:00pm | Shaler at South Fayette | 6-28 |
| 7:00pm | Shenango at Ellwood City | PPD |
| 7:00pm | South Allegheny at Brentwood | 50-7 |
| 7:00pm | Thomas Jefferson at Central Valley | 27-13 |
| 7:00pm | University Prep at Hickory | 14-40 |
| 7:00pm | Upper St. Clair at Canon-McMillan | 41-6 |
| 7:00pm | Washington at Steel Valley | 8-28 |
| 7:00pm | West Greene at Monessen | 6-62 |
| 7:00pm | West Mifflin at Avonworth | 22-28 |
| 7:00pm | Western Beaver at South Side Beaver | PPD |
| 7:00pm | Yough at Charleroi | 21-9 |
