| Class 6A |
| Quad-County Conference |
| 7:00pm | Mt. Lebanon at Central Catholic | 7-59 |
| 7:00pm | North Allegheny at Hempfield | 42-14 |
| 7:00pm | Seneca Valley at Norwin | 26-6 |
| Class 5A |
| Big East Conference |
| 7:00pm | Gateway at Kiski Area | 28-7 |
| 7:00pm | Latrobe at Franklin Regional | 0-3 |
| 7:30pm | Woodland Hills at Penn-Trafford | 35-21 |
| Northeast Conference |
| 7:00pm | North Hills at Pine-Richland | 24-29 |
| 7:00pm | Penn Hills at Fox Chapel | 54-0 |
| 7:00pm | Shaler at Plum | 7-24 |
| Class 3A |
| Allegheny 7 Conference |
| 7:00pm | East Allegheny at Highlands | 36-64 |
| 7:00pm | Freeport at Deer Lakes | 21-28 |
| 7:00pm | Imani Christian at Valley | 46-0 |
| Western Hills Conference |
| 7:00pm | Central Valley at McGuffey | 49-0 |
| 7:00pm | Hopewell at Beaver Area | 17-49 |
| 7:00pm | Quaker Valley at North Catholic | 0-38 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Our Lady of Sacred Heart at South Allegheny | 7-23 |
| 7:00pm | Shady Side Academy at Ligonier Valley | 28-40 |
| 7:00pm | Steel Valley at South Park | 0-7 |
| Century Conference |
| 7:00pm | Seton LaSalle at Charleroi | 48-8 |
| 7:00pm | Sto-Rox at Keystone Oaks | 8-24 |
| 7:00pm | Waynesburg Central at Washington | 21-13 |
| Midwestern Conference |
| 7:00pm | Freedom at New Brighton | 24-32 |
| 7:00pm | Mohawk at Ellwood City | 34-41 |
| 7:00pm | Union at Riverside | 6-21 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Rochester at Neshannock | 0-21 |
| 7:00pm | Shenango at Northgate | 25-20 |
| 7:00pm | Summit Academy at South Side Beaver | 14-42 |
| Black Hills Conference |
| 7:00pm | Chartiers-Houston at Fort Cherry | 6-42 |
| 7:00pm | Cornell at Burgettstown | 42-0 |
| 7:00pm | Serra Catholic at Monessen | 14-20 |
| Eastern Conference |
| 7:00pm | Brentwood at Springdale | 48-6 |
| 7:00pm | Frazier at Jeannette | 24-43 |
| 7:00pm | Greensburg Central Catholic at Clairton | 0-47 |
| 7:00pm | Riverview at Leechburg | 14-43 |
| Tri-County South Conference |
| 7:00pm | Avella at West Greene | 12-23 |
| 7:00pm | Beth-Center at Carmichaels | 0-18 |
| 7:00pm | California at Bentworth | 72-14 |
| 7:00pm | Mapletown at Jefferson-Morgan | 14-62 |
| Non Conference |
| 7:00pm | Albert Gallatin at Northern Garrett, Md. | 21-31 |
| 7:00pm | Allderdice at Uniontown | 21-15 |
| 7:00pm | Apollo-Ridge at Carlynton | 15-42 |
| 7:00pm | Avonworth at Thomas Jefferson | 7-44 |
| 7:00pm | Baldwin at Chartiers Valley | 13-21 |
| 7:00pm | Belle Vernon at McKeesport | 7-28 |
| 7:00pm | Berlin-Brothersvalley at Connellsville | 7-19 |
| 7:00pm | Bishop Canevin at Laurel | 48-23 |
| 7:00pm | Blackhawk at Southmoreland | 45-20 |
| 7:00pm | Brownsville at Bellaire, Ohio | 0-41 |
| 7:00pm | Butler at Hollidaysburg | 0-24 |
| 7:00pm | Canon-McMillan at Armstrong | 45-35 |
| 7:00pm | Carrick at Brashear | 36-2 |
| 7:00pm | Derry Area at Burrell | 32-13 |
| 7:00pm | Greensburg Salem at Ringgold | 7-0 |
| 7:00pm | Indiana at Laurel Highlands | 7-10 |
| 7:00pm | Knoch at Montour | 14-44 |
| 7:00pm | Mars at Aliquippa | 17-42 |
| 7:00pm | Mount Pleasant at Ambridge | 10-28 |
| 7:00pm | New Castle at Yough | 27-7 |
| 7:00pm | South Fayette at Elizabeth Forward | 38-19 |
| 7:00pm | Trinity at Peters Township | 6-35 |
| 7:00pm | University Prep at Steubenville, Ohio | 8-38 |
| 7:00pm | Upper St. Clair at Hampton | 62-7 |
| 7:00pm | West Allegheny at Moon | 24-32 |
| 7:00pm | West Mifflin at Bethel Park | 14-62 |
