| Class 6A |
| Quad-County Conference |
| 7:00pm | Canon-McMillan at Mt. Lebanon | 17-14 OT |
| 7:00pm | Central Catholic at Hempfield | 42-0 |
| 7:30pm | Norwin at North Allegheny | 14-36 |
| Class 5A |
| Big East Conference |
| 7:00pm | Armstrong at Latrobe | 0-14 |
| 7:00pm | Franklin Regional at Gateway | 36-34 |
| 7:00pm | Penn-Trafford at Kiski Area | 33-7 |
| Northeast Conference |
| 7:00pm | Fox Chapel at North Hills | 7-48 |
| 7:00pm | Pine-Richland at Plum | 43-7 |
| Class 3A |
| Allegheny 7 Conference |
| 7:00pm | Burrell at Freeport | 0-42 |
| 7:00pm | Deer Lakes at East Allegheny | 47-35 |
| 7:00pm | Highlands at Imani Christian | 10-12 |
| Western Hills Conference |
| 7:00pm | Avonworth at Hopewell | 50-19 |
| 7:00pm | Beaver Area at Central Valley | 37-51 |
| 7:00pm | North Catholic at McGuffey | 42-0 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Ligonier Valley at Our Lady of Sacred Heart | 7-28 |
| 7:00pm | South Park at South Allegheny | 48-38 |
| Century Conference |
| 7:00pm | Charleroi at Keystone Oaks | 7-14 |
| 7:00pm | Washington at Sto-Rox | 41-16 |
| Midwestern Conference |
| 7:00pm | Beaver Falls at Mohawk | 0-23 |
| 7:00pm | Ellwood City at Freedom | 43-3 |
| 7:00pm | Riverside at New Brighton | 20-13 |
| 7:00pm | Western Beaver at Union | 33-6 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Laurel at Rochester | 23-12 |
| 7:00pm | Neshannock at Northgate | 41-14 |
| 7:00pm | South Side Beaver at Shenango | 34-21 |
| Black Hills Conference |
| 7:00pm | Bishop Canevin at Cornell | 29-22 |
| 7:00pm | Burgettstown at Chartiers-Houston | 11-19 |
| 7:00pm | Fort Cherry at Monessen | 35-14 |
| Eastern Conference |
| 7:00pm | Brentwood at Greensburg Central Catholic | 12-34 |
| 7:00pm | Clairton at Frazier | 60-0 |
| 7:00pm | Leechburg at Jeannette | 35-13 |
| Tri-County South Conference |
| 7:00pm | Avella at California | 0-40 |
| 7:00pm | Bentworth at Beth-Center | 45-32 |
| 7:00pm | Jefferson-Morgan at Carmichaels | 21-6 |
| 7:00pm | West Greene at Mapletown | 37-8 |
| City League Class 6A/5A/4A/3A |
| 7:00pm | University Prep at Perry Traditional Academy | 52-6 |
| Non Conference |
| 7:00pm | Albert Gallatin at Uniontown | 36-21 |
| 7:00pm | Aliquippa at Penn Hills | 13-21 |
| 7:00pm | Ambridge at Greensburg Salem | 27-8 |
| 7:00pm | Connellsville at Morgantown, W.Va. | 7-21 |
| 7:00pm | Elizabeth Forward at Baldwin | 40-0 |
| 7:00pm | Hampton at Chartiers Valley | 34-27 |
| 7:00pm | Indiana at Derry Area | 0-21 |
| 7:00pm | Knoch at New Castle | 32-42 |
| 7:00pm | Laurel Highlands at Mount Pleasant | 21-20 OT |
| 7:00pm | Martins Ferry, Ohio at Brownsville | 49-0 |
| 7:00pm | Montour at Mars | 31-14 |
| 7:00pm | Moon at Seneca Valley | 42-13 |
| 7:00pm | Peters Township at West Allegheny | 38-0 |
| 7:00pm | South Fayette at Belle Vernon | 27-14 |
| 7:00pm | Southmoreland at Ringgold | 32-15 |
| 7:00pm | Thomas Jefferson at West Mifflin | 35-7 |
| 7:00pm | Trinity at Bethel Park | 7-49 |
| 7:00pm | Upper St. Clair at McKeesport | 31-14 |
| 7:00pm | Valley at Quaker Valley | 14-34 |
| 7:00pm | Waynesburg Central at Steel Valley | 6-40 |
| 7:00pm | Westinghouse at Butler | 28-17 |
| 7:00pm | Yough at Blackhawk | 6-57 |
