| Class 6A |
| Quad County Conference |
| 7:00pm | Canon-McMillan at Hempfield | 34-38 OT |
| 7:00pm | Central Catholic at Seneca Valley | 62-0 |
| 7:00pm | Mt. Lebanon at Norwin | 3-22 |
| Class 5A |
| Big East Conference |
| 7:00pm | Fox Chapel at Franklin Regional | 0-35 |
| 7:00pm | Latrobe at Woodland Hills | 6-41 |
| 7:00pm | Penn-Trafford at Connellsville | 64-0 |
| Northeast Conference |
| 7:00pm | North Hills at Penn Hills | 43-9 |
| Class 3A |
| Allegheny Seven Conference |
| 7:00pm | Knoch at Freeport | 0-27 |
| 7:00pm | North Catholic at Burrell | 32-20 |
| 7:00pm | Valley at Highlands | 6-48 |
| Interstate Conference |
| 7:00pm | Elizabeth Forward at Southmoreland | 41-0 |
| 7:00pm | Greensburg Salem at Belle Vernon | 14-49 |
| 7:00pm | Mount Pleasant at Waynesburg Central | 44-14 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Brownsville at South Allegheny | 12-52 |
| 7:00pm | Charleroi at Apollo-Ridge | 18-57 |
| 7:00pm | Steel Valley at East Allegheny | 26-0 |
| Century Conference |
| 7:00pm | McGuffey at Bishop Canevin | 14-21 |
| 7:00pm | Quaker Valley at Keystone Oaks | 6-29 |
| 7:00pm | Seton LaSalle at Chartiers-Houston | 65-24 |
| Midwestern Conference |
| 7:00pm | Beaver Falls at Freedom | 24-13 |
| 7:00pm | Mohawk at Neshannock | 6-48 |
| 7:00pm | New Brighton at Riverside | 22-33 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Northgate at South Side | 21-20 |
| 7:00pm | Rochester at Shenango | 8-49 |
| 7:00pm | Union at Cornell | 22-20 OT |
| Black Hills Conference |
| 7:00pm | Brentwood at Bentworth | 17-20 OT |
| 7:00pm | Burgettstown at Monessen | 10-6 |
| 7:00pm | Sto-Rox at Fort Cherry | 8-49 |
| Eastern Conference |
| 7:00pm | Greensburg Central Catholic at Springdale | 56-7 |
| 7:00pm | Riverview at Jeannette | 7-14 |
| 7:00pm | Serra Catholic at Leechburg | 28-20 |
| Tri-County South Conference |
| 7:00pm | Beth-Center at West Greene | 35-0 |
| 7:00pm | California at Frazier | 36-0 |
| 7:00pm | Carmichaels at Avella | 14-34 |
| 7:00pm | Mapletown at Jefferson-Morgan | 12-27 |
| City League Class 6A/5A/4A/3A/2A City League |
| 7:30pm | Perry Traditional Academy at Westinghouse | 6-55 |
| 3:30pm | University Prep at Brashear | 16-13 |
| Non Conference |
| 7:00pm | Albert Gallatin at Indiana | 14-25 |
| 7:00pm | Armstrong at Gateway | 14-12 |
| 7:00pm | Avonworth at Beaver Area | 49-6 |
| 7:00pm | Carlynton at Ligonier Valley | 12-52 |
| 7:00pm | Chartiers Valley at Bethel Park | 27-24 |
| 7:00pm | Clairton at Washington | 8-7 |
| 7:00pm | Derry Area at Deer Lakes | 26-48 |
| 7:00pm | Ellwood City at Shady Side Academy | 13-27 |
| 7:00pm | Grove City at Ambridge | 42-12 |
| 7:00pm | Hampton at Central Valley | 16-14 |
| 7:00pm | Hickory at Butler | 34-18 |
| 7:00pm | Laurel Highlands at West Mifflin | 0-39 |
| 7:00pm | Montour at Thomas Jefferson | 29-34 |
| 7:00pm | Moon at West Allegheny | 13-21 |
| 7:00pm | North Allegheny at Pine-Richland | 7-40 |
| 7:00pm | Peters Township at McKeesport | 20-10 |
| 7:00pm | Plum at Kiski Area | 29-28 |
| 7:00pm | Propel Braddock Hills at Our Lady of Sacred Heart | 51-12 |
| 7:00pm | Shaler at Blackhawk | 31-40 |
| 7:00pm | South Fayette at Upper St. Clair | 7-31 |
| 7:00pm | South Park at Ringgold | 7-46 |
| 7:00pm | Trinity at Mars | 27-21 |
| 7:00pm | Western Beaver at Hopewell | 6-47 |
| 7:00pm | Yough at Uniontown | 0-62 |
