| Class 6A |
| Quad County Conference |
| 7:30pm | Hempfield at North Allegheny | 7-14 |
| 7:00pm | Norwin at Central Catholic | 17-54 |
| 7:00pm | Seneca Valley at Canon-McMillan | 8-38 |
| Class 5A |
| Big East Conference |
| 7:00pm | Franklin Regional at Penn-Trafford | 0-68 |
| 7:00pm | Latrobe at Gateway | 24-7 |
| 6:00pm | Woodland Hills at Fox Chapel | 42-3 |
| Class 3A |
| Allegheny Seven Conference |
| 7:00pm | Deer Lakes at Valley | 50-13 |
| 7:00pm | Freeport at North Catholic | 28-42 |
| 7:00pm | Highlands at Knoch | 28-14 |
| Interstate Conference |
| 7:00pm | Derry Area at Mount Pleasant | 20-31 |
| 7:00pm | Southmoreland at Greensburg Salem | 42-34 |
| 7:00pm | Waynesburg Central at Elizabeth Forward | 33-38 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Apollo-Ridge at Brownsville | 56-13 |
| 7:00pm | Charleroi at Ligonier Valley | 20-56 |
| 7:00pm | East Allegheny at South Allegheny | 34-54 |
| Century Conference |
| 7:00pm | Bishop Canevin at Carlynton | 49-0 |
| 7:00pm | Chartiers-Houston at Keystone Oaks | 40-6 |
| 7:00pm | McGuffey at Quaker Valley | 48-9 |
| Midwestern Conference |
| 7:00pm | Freedom at Mohawk | 39-23 |
| 7:00pm | Neshannock at New Brighton | 44-6 |
| 7:00pm | Riverside at Western Beaver | 10-28 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Cornell at Laurel | 6-48 |
| 7:00pm | Shenango at Northgate | 30-22 |
| 7:00pm | South Side at Union | 0-35 |
| 7:00pm | Summit Academy at Rochester | 0-44 |
| Black Hills Conference |
| 7:00pm | Fort Cherry at Monessen | 12-14 |
| 7:00pm | Sto-Rox at Burgettstown | 0-28 |
| 7:00pm | Washington at Brentwood | 48-14 |
| Eastern Conference |
| 7:00pm | Riverview at Leechburg | 44-7 |
| 7:00pm | Serra Catholic at Clairton | 12-50 |
| 7:00pm | Springdale at Jeannette | 0-42 |
| Tri-County South Conference |
| 7:00pm | Beth-Center at Avella | 62-14 |
| 7:00pm | Carmichaels at California | 8-46 |
| 7:00pm | Jefferson-Morgan at Frazier | 7-46 |
| 7:00pm | West Greene at Mapletown | 37-26 |
| City League Class 6A/5A/4A/3A |
| 7:30pm | Allderdice at University Prep | 8-46 |
| 3:30pm | Carrick at Westinghouse | 0-49 |
| Non Conference |
| 7:00pm | Albert Gallatin at Yough | 42-14 |
| 7:00pm | Baldwin at Hollidaysburg | 12-49 |
| 7:00pm | Beaver Area at Beaver Falls | 27-28 OT |
| 7:00pm | Bentworth at Greensburg Central Catholic | 0-28 |
| 7:00pm | Bethel Park at Penn Hills | 35-14 |
| 7:00pm | Blackhawk at Ellwood City | 49-14 |
| 7:00pm | Burrell at Belle Vernon | 0-35 |
| 7:00pm | Butler at Austintown-Fitch, Ohio | 6-77 |
| 7:00pm | Central Valley at Hopewell | 6-34 |
| 7:00pm | Indiana at Armstrong | 8-42 |
| 7:00pm | Laurel Highlands at South Park | 0-35 |
| 7:00pm | Mars at Hampton | 14-7 |
| 7:00pm | Moon at Thomas Jefferson | 35-70 |
| 7:00pm | New Castle at Avonworth | 14-34 |
| 7:00pm | North Hills at Peters Township | 10-0 |
| 7:00pm | Our Lady of Sacred Heart at Berlin-Brothersvalley | 0-16 |
| 7:00pm | Pine-Richland at Mt. Lebanon | 41-6 |
| 7:00pm | Ringgold at Kiski Area | 14-21 OT |
| 7:00pm | Seton LaSalle at Steel Valley | 54-0 |
| 7:00pm | Shady Side Academy at Aliquippa | 8-49 |
| 7:00pm | Shaler at Plum | 6-42 |
| 7:00pm | South Fayette at Trinity | 21-0 |
| 7:00pm | Uniontown at Connellsville | 13-25 |
| 7:00pm | Upper St. Clair at Chartiers Valley | 49-7 |
| 7:00pm | West Allegheny at Montour | 20-21 |
| 7:00pm | West Mifflin at Ambridge | 20-0 |
