| Class 6A |
| Quad County Conference |
| 7:00pm | Mt. Lebanon at Hempfield | |
| 7:00pm | Norwin at Canon-McMillan | |
| 7:30pm | Seneca Valley at North Allegheny | |
| Class 5A |
| Allegheny Six Conference |
| 7:00pm | Bethel Park at Thomas Jefferson | |
| 7:00pm | Upper St. Clair at Trinity | |
| 7:00pm | West Allegheny at Peters Township | |
| Big East Conference |
| 7:00pm | Gateway at Penn-Trafford | |
| 7:00pm | Shaler at Kiski Area | |
| 7:00pm | Woodland Hills at Franklin Regional | |
| Northeast Conference |
| 7:00pm | Armstrong at Pine-Richland | |
| 7:00pm | Penn Hills at Moon | |
| 7:00pm | Plum at North Hills | |
| Class 4A |
| Big Six Conference |
| 7:00pm | Albert Gallatin at Ringgold | |
| 7:00pm | Chartiers Valley at Uniontown | |
| 7:00pm | South Fayette at Laurel Highlands | |
| 7:00pm | Southmoreland at Belle Vernon | |
| Greater Allegheny Conference |
| 7:00pm | Hampton at McKeesport | |
| 7:00pm | New Castle at Mars | |
| Parkway Conference |
| 7:00pm | Central Valley at Blackhawk | |
| Class 3A |
| Allegheny Seven Conference |
| 7:00pm | Deer Lakes at Freeport | |
| 7:00pm | Highlands at Burrell | |
| 7:00pm | Valley at Knoch | |
| Interstate Conference |
| 7:00pm | Greensburg Salem at Mount Pleasant | |
| Northwestern Six Conference |
| 7:00pm | South Park at Propel Braddock Hills | |
| Western Hills Conference |
| 7:00pm | Aliquippa at Beaver Area | |
| 7:00pm | West Mifflin at Avonworth | |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Charleroi at East Allegheny | |
| 7:00pm | Steel Valley at Apollo-Ridge | |
| Century Conference |
| 7:00pm | Bishop Canevin at Keystone Oaks | |
| 7:00pm | Carlynton at Chartiers-Houston | |
| 7:00pm | Derry Area at Waynesburg Central | |
| 7:00pm | Seton LaSalle at Quaker Valley | |
| Midwestern Conference |
| 7:00pm | Beaver Falls at Riverside | |
| 7:00pm | Freedom at Western Beaver | |
| 7:00pm | Mohawk at New Brighton | |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Rochester at Laurel | |
| 7:00pm | Shenango at Union | |
| 7:00pm | South Side Beaver at Cornell | |
| Black Hills Conference |
| 7:00pm | Bentworth at Sto-Rox | |
| 7:00pm | Burgettstown at Brentwood | |
| 7:00pm | Washington at Monessen | |
| Eastern Conference |
| 7:00pm | Clairton at Leechburg | |
| 7:00pm | Greensburg Central Catholic at Riverview | |
| 7:00pm | Serra Catholic at Springdale | |
| Tri-County South Conference |
| 7:00pm | Avella at Mapletown | |
| 7:00pm | Carmichaels at West Greene | |
| 7:00pm | Frazier at Beth-Center | |
| 7:00pm | Jefferson-Morgan at California | |
| City League Class AAAA Class 6A/5A/4A/3A |
| 7:00pm | Westinghouse at Allderdice | |
| City League Class 6A/5A/4A/3A/2A City League |
| 3:30pm | University Prep at Perry Traditional Academy | |
| Non Conference |
| 7:00pm | Baldwin at DuBois Area | |
| 7:00pm | Butler at Karns City | |
| 7:00pm | Fort Cherry at Jeannette | |
| 7:00pm | Indiana at Fox Chapel | |
| 7:00pm | McGuffey at Brownsville | |
| 7:00pm | Montour at Elizabeth Forward | |
