| Non Conference |
| 7:00pm | Aliquippa at Belle Vernon | 42-7 |
| 7:00pm | Allderdice at Hollidaysburg | 16-28 |
| 7:00pm | Ambridge at Laurel Highlands | 7-12 |
| 7:00pm | Avella at Carlynton | 7-6 |
| 7:00pm | Avonworth at West Mifflin | 37-7 |
| 7:00pm | Baldwin at Fox Chapel | 14-48 |
| 7:00pm | Beaver Area at Blackhawk | 50-27 |
| 7:00pm | Bentworth at Burgettstown | 20-23 |
| 7:00pm | Brashear at Butler | 24-48 |
| 7:00pm | Brentwood at South Allegheny | 6-49 |
| 7:00pm | Burrell at Shady Side Academy | 26-56 |
| 7:00pm | Canon-McMillan at Upper St. Clair | 0-48 |
| 7:00pm | Central Valley at Thomas Jefferson | 14-37 |
| 7:00pm | Charleroi at Yough | 7-42 |
| 7:00pm | Connellsville at Meadville | 14-35 |
| 7:00pm | Cornell at California | 32-36 |
| 7:00pm | Derry Area at Freeport | 6-49 |
| 7:00pm | Ellwood City at Shenango | 21-0 |
| 7:00pm | Fort Cherry at Our Lady of Sacred Heart | 40-0 |
| 7:00pm | Frazier at Mapletown | 21-22 |
| 7:00pm | Greensburg Central Catholic at Mount Pleasant | 40-7 |
| 7:00pm | Greensburg Salem at Ligonier Valley | 14-12 |
| 7:00pm | Hampton at Armstrong | 28-35 |
| 7:00pm | Hempfield at Franklin Regional | 31-14 |
| 7:00pm | Hickory at University Prep | 41-24 |
| 7:00pm | Highlands at Elizabeth Forward | 14-35 |
| 7:00pm | Imani Christian at Beaver Falls | 58-0 |
| 7:00pm | Indiana at Ringgold | 14-61 |
| 7:00pm | Jeannette at Apollo-Ridge | 35-22 |
| 7:00pm | Kiski Area at Norwin | 7-42 |
| 7:00pm | Knoch at North Catholic | 10-69 |
| 7:00pm | Latrobe at Plum | 42-35 3OT |
| 7:00pm | Leechburg at Beth-Center | 58-6 |
| 7:00pm | Mars at Bethel Park | 17-13 |
| 7:00pm | Mohawk at Laurel | 6-36 |
| 7:00pm | Monessen at West Greene | 34-18 |
| 7:00pm | Moon at Montour | 41-13 |
| 7:00pm | New Castle at Hopewell | 6-31 |
| 7:00pm | North Allegheny at Gateway | 41-0 |
| 7:00pm | North Hills at Seneca Valley | 10-38 |
| 7:00pm | Penn-Trafford at Mt. Lebanon | 26-18 |
| 7:00pm | Peters Township at McKeesport | 35-0 |
| 7:00pm | Pine-Richland at Central Catholic | 20-34 |
| 7:00pm | Quaker Valley at Keystone Oaks | 20-13 |
| 7:00pm | Riverside at Northgate | 36-30 |
| 7:00pm | Rochester at Freedom | 0-18 |
| 7:00pm | Serra Catholic at Clairton | 0-79 |
| 7:00pm | South Fayette at Shaler | 35-27 |
| 7:00pm | South Park at Deer Lakes | 35-14 |
| 7:00pm | South Side Beaver at Western Beaver | 20-32 |
| 7:00pm | Southmoreland at East Allegheny | 49-7 |
| 7:00pm | Springdale at Chartiers-Houston | 8-42 |
| 7:00pm | St. Clairsville, Ohio at Brownsville | 49-13 |
| 7:00pm | Steel Valley at Washington | 21-6 |
| 7:00pm | Sto-Rox at Carmichaels | 20-38 |
| 7:00pm | Summit Academy at New Brighton | 14-42 |
| 7:00pm | Trinity at McGuffey | 35-13 |
| 7:00pm | Union at Neshannock | 6-42 |
| 3:30pm | Uniontown at Perry Traditional Academy | 12-8 |
| 7:00pm | Waynesburg Central at Jefferson-Morgan | 30-57 |
| 7:00pm | West Allegheny at Chartiers Valley | 28-29 OT |
| 7:00pm | Woodland Hills at Penn Hills | 41-7 |
