| City League Class 5A/4A/3A/2A/1A |
| 7:00pm | Allderdice at Perry Traditional Academy | 45-6 |
| Non Conference |
| 7:00pm | Albert Gallatin at Connellsville | 28-14 |
| 7:00pm | Apollo-Ridge at Greensburg Central Catholic | 16-35 |
| 7:00pm | Armstrong at Bethel Park | 28-56 |
| 7:00pm | Avella at Springdale | 35-6 |
| 7:00pm | Avonworth at Aliquippa | 23-7 |
| 7:00pm | Beaver Falls at South Side Beaver | 6-26 |
| 7:00pm | Belle Vernon at Central Valley | 25-22 |
| 7:00pm | Bentworth at Charleroi | 45-0 |
| 7:00pm | Beth-Center at Monessen | 3-20 |
| 7:00pm | Bishop Canevin at Steel Valley | 21-6 |
| 7:00pm | Blackhawk at North Catholic | 49-65 |
| 7:00pm | Brentwood at Sto-Rox | 41-0 |
| 7:00pm | Brownsville at Uniontown | 27-34 |
| 7:00pm | California at Waynesburg Central | 20-27 |
| 7:00pm | Carmichaels at Frazier | 14-31 |
| 7:00pm | Chartiers-Houston at Mapletown | 35-28 |
| 7:00pm | Derry Area at Deer Lakes | 24-21 |
| 7:00pm | East Allegheny at Elizabeth Forward | 13-60 |
| 7:00pm | Fox Chapel at Knoch | 20-18 |
| 7:00pm | Freeport at Quaker Valley | 42-7 |
| 7:00pm | Greensburg Salem at Valley | 26-10 |
| 7:00pm | Hampton at Shaler | 25-24 |
| 7:00pm | Hopewell at Ambridge | 49-2 |
| 7:00pm | Imani Christian at Beaver Area | 41-3 |
| 7:00pm | Indiana at Chartiers Valley | 6-42 |
| 7:00pm | Jefferson-Morgan at Burgettstown | 26-10 |
| 7:00pm | Kiski Area at Hempfield | 10-43 |
| 7:00pm | Laurel at Riverside | 43-0 |
| 7:00pm | Laurel Highlands at Southmoreland | 7-54 |
| 7:00pm | Ligonier Valley at Jeannette | 0-31 |
| 7:00pm | Mars at North Hills | 13-10 |
| 7:00pm | Meadville at Butler | 34-48 |
| 7:00pm | Mount Pleasant at Burrell | 21-28 |
| 7:00pm | Mt. Lebanon at Peters Township | 0-35 |
| 7:00pm | Neshannock at Ellwood City | 26-20 |
| 7:00pm | New Brighton at Northgate | 38-0 |
| 7:00pm | New Castle at Highlands | 32-0 |
| 7:00pm | Norwin at Latrobe | 35-0 |
| 7:00pm | Our Lady of Sacred Heart at Seton LaSalle | 7-39 |
| 7:30pm | Penn Hills at North Allegheny | 0-35 |
| 7:00pm | Penn-Trafford at Moon | 25-24 |
| 7:00pm | Plum at Gateway | 23-14 |
| 7:00pm | Riverview at Cornell | 21-35 |
| 7:00pm | Seneca Valley at Pine-Richland | 20-49 |
| 7:00pm | Serra Catholic at Leechburg | 0-26 |
| 7:00pm | Shady Side Academy at Clairton | 0-1 F |
| 7:00pm | Shenango at Mohawk | 24-0 |
| 7:00pm | South Allegheny at Carlynton | 53-0 |
| 7:00pm | South Fayette at Canon-McMillan | 28-37 |
| 7:00pm | South Park at Keystone Oaks | 27-14 |
| 7:00pm | Thomas Jefferson at McKeesport | 16-7 |
| 7:00pm | Trinity at Montour | 27-35 |
| 3:30pm | University Prep at Carrick | 56-12 |
| 7:00pm | Upper St. Clair at Franklin Regional | 49-6 |
| 7:00pm | Washington at Union | 44-6 |
| 7:00pm | West Allegheny at McGuffey | 65-7 |
| 7:00pm | West Greene at Fort Cherry | 8-55 |
| 7:00pm | West Mifflin at Baldwin | 41-0 |
| 7:00pm | Western Beaver at Rochester | 41-6 |
| 7:00pm | Yough at Ringgold | 0-40 |
