| Class 6A |
| Quad-County Conference |
| 7:00pm | Central Catholic at Mt. Lebanon | 57-0 |
| 7:30pm | Hempfield at North Allegheny | 13-56 |
| 7:00pm | Norwin at Seneca Valley | 56-13 |
| Class 5A |
| Big East Conference |
| 7:00pm | Franklin Regional at Latrobe | 7-13 |
| 7:00pm | Kiski Area at Gateway | 31-34 |
| 7:00pm | Penn-Trafford at Woodland Hills | 21-49 |
| Northeast Conference |
| 7:00pm | Fox Chapel at Penn Hills | 14-49 |
| 7:00pm | Pine-Richland at North Hills | 48-6 |
| 7:00pm | Plum at Shaler | 20-27 |
| Class 3A |
| Allegheny 7 Conference |
| 7:00pm | Deer Lakes at Freeport | 7-58 |
| 7:00pm | Highlands at East Allegheny | 42-15 |
| 7:00pm | Valley at Imani Christian | 0-72 |
| Western Hills Conference |
| 7:00pm | Beaver Area at Hopewell | 51-50 |
| 7:00pm | McGuffey at Central Valley | 6-49 |
| 7:00pm | North Catholic at Quaker Valley | 49-0 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Ligonier Valley at Shady Side Academy | 6-42 |
| 7:00pm | South Allegheny at Our Lady of Sacred Heart | 28-6 |
| 7:00pm | South Park at Steel Valley | 7-56 |
| Century Conference |
| 7:00pm | Charleroi at Seton LaSalle | 14-61 |
| 7:00pm | Keystone Oaks at Sto-Rox | 28-0 |
| 7:00pm | Washington at Waynesburg Central | 35-14 |
| Midwestern Conference |
| 7:00pm | Ellwood City at Mohawk | 21-15 |
| 7:00pm | New Brighton at Freedom | 0-42 |
| 7:00pm | Western Beaver at Beaver Falls | 36-8 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Northgate at Shenango | 20-56 |
| Black Hills Conference |
| 7:00pm | Burgettstown at Cornell | 13-18 |
| 7:00pm | Fort Cherry at Chartiers-Houston | 44-14 |
| 7:00pm | Monessen at Serra Catholic | 13-6 |
| Eastern Conference |
| 7:00pm | Clairton at Greensburg Central Catholic | 43-0 |
| 7:00pm | Jeannette at Frazier | 61-19 |
| 7:00pm | Leechburg at Riverview | 27-18 |
| 7:00pm | Springdale at Brentwood | 0-42 |
| Tri-County South Conference |
| 7:00pm | Bentworth at California | 7-8 |
| 7:00pm | Carmichaels at Beth-Center | 6-35 |
| 7:00pm | Jefferson-Morgan at Mapletown | 63-6 |
| 7:00pm | West Greene at Avella | 6-18 |
| City League Class 5A/4A/3A/2A/1A |
| 7:30pm | Perry Traditional Academy at Westinghouse | 0-76 |
| Non Conference |
| 7:00pm | Aliquippa at Mars | 19-6 |
| 7:00pm | Ambridge at Mount Pleasant | 27-28 |
| 7:00pm | Armstrong at Canon-McMillan | 21-31 |
| 7:00pm | Bethel Park at West Mifflin | 41-7 |
| 7:00pm | Burrell at Derry Area | 7-13 |
| 7:00pm | Carlynton at Apollo-Ridge | 0-42 |
| 7:00pm | Chartiers Valley at Baldwin | 62-12 |
| 7:00pm | Connellsville at Spring Mills, W.Va. | 0-52 |
| 7:00pm | Elizabeth Forward at South Fayette | 24-27 |
| 7:00pm | Hampton at Upper St. Clair | 3-62 |
| 7:00pm | Hollidaysburg at Butler | 33-6 |
| 7:00pm | Laurel Highlands at Indiana | 7-48 |
| 7:00pm | McKeesport at Belle Vernon | 20-7 |
| 7:00pm | Montour at Knoch | 41-8 |
| 7:00pm | Moon at West Allegheny | 21-3 |
| 7:00pm | Northern Garrett, Md. at Albert Gallatin | 24-40 |
| 7:00pm | Peters Township at Trinity | 31-12 |
| 7:00pm | Ringgold at Greensburg Salem | 33-13 |
| 7:00pm | Southmoreland at Blackhawk | 24-17 |
| 7:00pm | Thomas Jefferson at Avonworth | 14-41 |
| 3:30pm | Uniontown at Allderdice | 0-40 |
| 7:00pm | Yough at New Castle | 0-53 |
