| Class 6A |
| Quad-County Conference |
| 7:00pm | Hempfield at Central Catholic | 7-59 |
| 7:00pm | Mt. Lebanon at Canon-McMillan | 6-21 |
| 7:00pm | North Allegheny at Norwin | 20-17 |
| Class 5A |
| Big East Conference |
| 7:00pm | Gateway at Franklin Regional | 33-28 |
| 7:00pm | Kiski Area at Penn-Trafford | 0-42 |
| 7:00pm | Latrobe at Armstrong | 14-17 |
| Northeast Conference |
| 7:00pm | North Hills at Fox Chapel | 56-7 |
| 7:00pm | Plum at Pine-Richland | 14-56 |
| Class 3A |
| Allegheny 7 Conference |
| 7:00pm | East Allegheny at Deer Lakes | 14-7 |
| 7:00pm | Freeport at Burrell | 34-7 |
| 7:00pm | Imani Christian at Highlands | 27-7 |
| Western Hills Conference |
| 7:00pm | Central Valley at Beaver Area | 51-19 |
| 7:00pm | Hopewell at Avonworth | 6-48 |
| 7:00pm | McGuffey at North Catholic | 0-63 |
| Class 2A |
| Allegheny Conference |
| 7:00pm | Our Lady of Sacred Heart at Ligonier Valley | 40-6 |
| 7:00pm | Shady Side Academy at Apollo-Ridge | 14-22 |
| 7:00pm | South Allegheny at South Park | 56-7 |
| Century Conference |
| 7:00pm | Keystone Oaks at Charleroi | 42-7 |
| 7:00pm | Seton LaSalle at Carlynton | 49-0 |
| 7:00pm | Sto-Rox at Washington | 6-49 |
| Midwestern Conference |
| 7:00pm | Freedom at Ellwood City | 14-28 |
| 7:00pm | Mohawk at Beaver Falls | 6-8 |
| 7:00pm | New Brighton at Riverside | 6-40 |
| 7:00pm | Union at Western Beaver | 14-46 |
| Class 1A |
| Big 7 Conference |
| 7:00pm | Northgate at Neshannock | 27-62 |
| 7:00pm | Rochester at Laurel | 0-40 |
| 7:00pm | Shenango at South Side Beaver | 7-35 |
| Black Hills Conference |
| 7:00pm | Cornell at Bishop Canevin | 7-44 |
| 7:00pm | Monessen at Fort Cherry | 6-55 |
| Eastern Conference |
| 7:00pm | Frazier at Clairton | 0-72 |
| 7:00pm | Greensburg Central Catholic at Brentwood | 34-6 |
| 7:00pm | Jeannette at Leechburg | 27-36 |
| 7:00pm | Riverview at Springdale | 64-14 |
| Tri-County South Conference |
| 7:00pm | Beth-Center at Bentworth | 7-42 |
| 7:00pm | California at Avella | 42-0 |
| 7:00pm | Carmichaels at Jefferson-Morgan | 0-33 |
| 7:00pm | Mapletown at West Greene | 0-40 |
| City League Class 5A/4A/3A/2A/1A |
| 7:00pm | Perry Traditional Academy at University Prep | 0-54 |
| Non Conference |
| 7:00pm | Baldwin at Elizabeth Forward | 0-57 |
| 7:00pm | Belle Vernon at South Fayette | 7-28 |
| 7:00pm | Bethel Park at Trinity | 51-35 |
| 7:00pm | Blackhawk at Yough | 49-6 |
| 7:00pm | Carrick at Buckeye Local, Ohio | 30-36 |
| 7:00pm | Chartiers Valley at Hampton | 22-13 |
| 7:00pm | Conotton Valley, Ohio at Brownsville | 46-0 |
| 7:00pm | Derry Area at Indiana | 34-41 |
| 7:00pm | Greensburg Salem at Ambridge | 32-42 |
| 7:00pm | Mars at Montour | 29-21 |
| 7:00pm | McKeesport at Upper St. Clair | 14-17 |
| 7:00pm | Morgantown, W.Va. at Connellsville | 48-21 |
| 7:00pm | Mount Pleasant at Laurel Highlands | 49-0 |
| 7:00pm | New Castle at Knoch | 45-0 |
| 7:00pm | Penn Hills at Aliquippa | 16-21 |
| 7:00pm | Quaker Valley at Valley | 29-20 |
| 7:00pm | Ringgold at Southmoreland | 7-28 |
| 7:00pm | Seneca Valley at Moon | 31-23 |
| 7:00pm | Shaler at Woodland Hills | 7-41 |
| 7:00pm | Summit Academy at Serra Catholic | 6-39 |
| 7:00pm | Uniontown at Albert Gallatin | 10-46 |
| 7:00pm | Waynesburg Central at Steel Valley | 0-34 |
| 7:00pm | West Allegheny at Peters Township | 0-28 |
| 7:00pm | West Mifflin at Thomas Jefferson | 14-35 |
| 7:00pm | Westinghouse at Butler | 0-1 F |
